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标题：Distribution of dermally absorbed 14C DDT in the organs of Wistar rats
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作者：Sabina Toś-Luty ; Małgorzata Tokarska-Rodak ; Jadwiga Latuszyńska 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2002
卷号：9
期号：2
页码：215-223
出版社：Institute of Agricultural Medicine in Lublin
摘要：The aim of study was evaluation of the concentration of dermally applied 1 4C DDT in the organs of rats, and evaluation of histological and ultrastructural changes after the dermal application of unlabelled DDT standard in the organs of rats, in which the presence of this pesticide was determined by the radio-isotopic method. 14C DDT of radiochemical purity of 97% was applied in the study. The activity of the preparation per 1 cm2of the tail skin was 22.2 KBq - (175.38 J''7 7KH PDWHULDO IRUWKHVWXG\was taken directly after single exposure and 6 h, 8 h, 10 h, 12 h, 14 h, 18 h and 20 h after exposure. The following organs were taken for the determination of radioactivity of tissues: brain, heart, lung, liver, kidney, skin at the site of exposure. Unlabelled chemically pure, DDT (99.7%) was used to evaluate histological and ultrastructural changes after dermal application. Experimental animals received an oil emulsion of DDT (10 mg/9 cm2), applied to the skin of the tail for 4 weeks. The time of exposure was 4h daily. The animals of the control group were dermally exposed to the emulsion at the same time and under the same conditions. 4 h after dermal exposure it was observed that the preparation applied on the surface of 9 cm2LQ WKHDPRXQWRIJwas present in the skin in the amount of 1 J cm2(0.11 JFP2), i.e. 0.063% of 1 4C DDT applied dose. Directly after dermal application lasting 4 h the greatest amount of 14C DDT was noted in the liver - J LH JJ +LVWRSDWRORJLFDO DQGultrastructural changes were observed in the liver, kidney, lungs and heart
关键词：14;C DDT - distribution in organs; DDT; dermal application; histopathology; ;ultrastructure