文章基本信息

标题：Tracking the establishment of local endemic populations of an emergent enteric pathogen
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作者：Kathryn E. Holt ; Tran Vu Thieu Nga ; Duy Pham Thanh 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2013
卷号：110
期号：43
页码：17522-17527
DOI：10.1073/pnas.1308632110
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population.
关键词：enteric disease ; drug resistance ; phylogeography ; genomics