文章基本信息

标题：PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB
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作者：Han Wei ; Benlian Wang ; Masaru Miyagi 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2013
卷号：110
期号：33
页码：13516-13521
DOI：10.1073/pnas.1311784110
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The ubiquitous inducible transcription factor NF-{kappa}B plays central roles in immune and inflammatory responses and in tumorigenesis. Complex posttranslational modifications of the p65 subunit (RelA) are a major aspect of the extremely flexible regulation of NF-{kappa}B activity. Although phosphorylation, acetylation, ubiquitination, and lysine methylation of NF-{kappa}B have been well described, arginine methylation has not yet been found. We now report that, in response to IL-1{beta
关键词：histone ; mass spectrometry