文章基本信息

标题：Technique for bone volume measurement from human femur head samples by classification of micro-CT image histograms
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作者：Franco Marinozzi ; Fabiano Bini ; Andrea Marinozzi 等
期刊名称：Annali dell'Istituto Superiore di Sanita
印刷版ISSN：0021-2571
出版年度：2013
卷号：49
期号：3
页码：300-305
DOI：10.4415/ANN_13_03_11
出版社：Editrice Kurtis Srl
摘要：Introduction. Micro-CT analysis is a powerful technique for a non-invasive evaluation of the morphometric parameters of trabecular bone samples. This elaboration requires a previous binarization of the images. A problem which arises from the binarization pro-cess is the partial volume artifact. Voxels at the external surface of the sample can contain both bone and air so thresholding operates an incorrect estimation of volume occupied by the two materials. Aim. The aim of this study is the extraction of bone volumetric information directly from the image histograms, by fitting them with a suitable set of functions.Methods. Nineteen trabecular bone samples were extracted from femoral heads of eight patients subject to a hip arthroplasty surgery. Trabecular bone samples were acquired us-ing micro-CT Scanner. Hystograms of the acquired images were computed and fitted by Gaussian-like functions accounting for: a) gray levels produced by the bone x-ray absorp-tion, b) the portions of the image occupied by air and c) voxels that contain a mixture of bone and air. This latter contribution can be considered such as an estimation of the partial volume effect.Results. The comparison of the proposed technique to the bone volumes measured by a reference instrument such as by a helium pycnometer show the method as a good way for an accurate bone volume calculation of trabecular bone samples
关键词：microtomography;. osteoarthritis; osteoporosis;. bone morphometry;. image processing