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标题：Pharmaco-epidemiological description of the population of the Marche Region (central Italy) treated with the antipsychotic drug olanzapine Fiorenzo Mignini, Maurizio Sabbatini, Chiara Pascucci, Fabio Petrelli, Iolanda Grappasonni and Nicola Vanacore
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作者：Fiorenzo Mignini(a) ; Maurizio Sabbatini(b) ; Chiara Pascucci(a) 等
期刊名称：Annali dell'Istituto Superiore di Sanita
印刷版ISSN：0021-2571
出版年度：2013
卷号：49
期号：1
页码：42-49
DOI：10.4415/ANN_13_01_08
出版社：Editrice Kurtis Srl
摘要：Background. In Italy, even though olanzapine has been discouraged for treatment of behaviour disorders in older patients affected by dementia, some physicians chose to prescribe for them. In response to this situation, the Italian Drug Agency (Agenzia Italiana del Farmaco, AIFA) promulgated a cautionary note. Materials and methods. This study examined epidemiological indices for olanzapine prescriptions between 2004 and 2007 in the Marche Region of central Italy and in its provinces, to assess physician compliance with the AIFA note, and to determine whether there were differences in drug prescription between populations of the same territory, or differences based on gender or age group. Results. Our analyses revealed high olanzapine use among young men and mature women, suggesting that these groups are most prone to psychotic symptoms. Analysis revealed that olanzapine prescription in elderly patients was reduced in some provinces, in line with the AIFA note. Conclusions. Prudent use of olanzapine prescription, in compliance with the AIFA note, was noted throughout the Region. Furthermore, this work offers details that may be useful in future studies of adverse drug reactions
关键词：psychiatric drug ;. prevalence index ;. incidence index ;. defined daily dose index