文章基本信息

标题：Cryptococcosis, A Risk for Immunocompromised and Immunocompetent Individuals
本地全文：下载
作者：Maurimélia Mesquita da Costa ; Francisco Martins Teixeira ; Taysa Ribeiro Schalcher 等
期刊名称：The Open Epidemiology Journal
电子版ISSN：1874-2971
出版年度：2013
卷号：6
期号：1
页码：9-17
DOI：10.2174/1874297101306010009
出版社：Bentham open
摘要：The genus Cryptococcus includes at least 37 different species, of which, two are important human pathogens: Cryptococcus neoformans and Cryptococcus gattii. These fungi are opportunistic pathogens and etiologic agents of cryptococcosis disease in humans and animals. A variety of virulence factors interfere with the establishment of cryptococcal infection is usually acquired via inhalation of environmental basidiospores or desiccated yeasts. Cryptococcosis has gained medical importance over the last decade due to the AIDS pandemic, and become an emerging pathogen of immunocompetent individuals, especially in children. This disease in humans may involve every tissue, including cutaneous and pulmonary sites, but the most serious manifestation is central nervous system involvement with meningoencephalitis. In this review, we briefly described the taxonomy, the fungus biology, epidemiology and clinical manifestations of cryptococcosis in immunocompetent and immunocompromised individuals.