This paper investigates the effect of unemployment and inflation on economic growth in Nigeria between 1986-2010 through the application of Augmented Dickey-Fuller technique in testing the unit root property of the series and Granger causality test of causation between GDP, unemployment and inflation. The results of unit root suggest that all the variables in the model are stationary and the results of Causality suggest that unemployment and inflation cause RGDP and not RGDP causing unemployment and inflation. The result shows a one-way causation running from unemployment and inflation to RGDP. The Johansen cointegration result shows that despite no causation between unemployment and inflation, but there existed 2 cointegrating equation, implying the existence of long run relationship between economic growth, unemployment and inflation. The results also revealed that unemployment and inflation possessed a positive impact on economic growth. The result also shows that unemployment does not significantly affect economic growth, but a good performance of an economy in terms of per capita growth may therefore be attributed to the rate of inflation in the country. A major policy implication of this result is that concerted effort should be made by policy makers to increase the level of output in Nigeria by improving productivity/supply in order to reduce unemployment and the prices of goods and services (inflation) so as to boost the growth of the economy. Another policy implication of this study is that government should embark on labour intensive technique of production as against capital intensive and also close the border to some extent which is the likely measure to reduce unemployment and Inflation and increase domestic output level (GDP).