文章基本信息

标题：Lipid-induced hepatic insulin resistance
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作者：Thomas Galbo ; Gerald I. Shulman
期刊名称：Aging
出版年度：2013
卷号：5
期号：8
页码：582-583
出版社：U.S.Department of Health & Human Service
摘要：The principal function of insulin in the liver is to suppress glucose production when blood glucose concentrations increase. This process is impaired in hepatic insulin resistance and contributes to postprandial hyperglycemia. The development of hepatic insulin resistance is very closely linked to non alcoholic fatty liver disease (NAFLD), and is a major factor in the pathogenesis of type 2 diabetes (T2D). Yet, the molecular mechanisms regarding the pathogenesis have remained elusive