文章基本信息

标题：M(o)TOR of aging: MTOR as a universal molecular hypothalamus
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作者：Mikhail V. Blagosklonny ; Mikhail V. Blagosklonny
期刊名称：Aging
出版年度：2013
卷号：5
期号：7
页码：490-494
出版社：U.S.Department of Health & Human Service
摘要：
A recent ground-breaking publication described hypothalamus-driven programmatic aging. As a Russian proverb goes "everything new is well-forgotten old". In 1958, Dilman proposed that aging and its related diseases are programmed by the hypothalamus. This theory, supported by beautiful experiments, remained unnoticed just to be re-discovered recently. Yet, it does not explain all manifestations of aging. And would organism age without hypothalamus? Do sensing pathways such as MTOR (mechanistic Target of Rapamycin) and IKK-beta play a role of a "molecular hypothalamus" in every cell? Are hypothalamus-driven alterations simply a part of quasi-programmed aging manifested by hyperfunction and secondary signal-resistance? Here are some answers.
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关键词：senescence; geroconversion; rapamycin; diseases; molecular hypothalamus