文章基本信息

标题：Flipping the tanycyte switch: how circulating signals gain direct access to the metabolic brain
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作者：Vincent Prevot ; Fanny Langlet ; Benedicte Dehouck 等
期刊名称：Aging
出版年度：2013
卷号：5
期号：5
页码：332-334
出版社：U.S.Department of Health & Human Service
摘要：The survival of an organism relies on its ability to promptly, effectively and reproducibly communicate with brain networks that control food intake and energy homeostasis [1, 2]. Although the access of most circulating factors to the brain requires transcellular transport across the blood-brain barrier, certain hypothalamic areas that play a critical role in the control of appetite and body weight, such as the arcuate nucleus of the hypothalamus (ARH), might require direct access to peripheral homeostatic signals by a privileged route that bypasses brain barriers. The question as to whether such a route exists and can be modulated to meet physiological demands in response to changes in feeding status is largely unexplored, and represents an issue central to our understanding of the mechanisms controlling energy balance and metabolism [3]. In a recent study, we have established a new physiological concept in the regulation of energy homeostasis by showing that the nutritional status of an individual modulates the permeability of discrete blood-hypothalamus barriers to circulating metabolic signals, permitting them to directly access a subset of ARH neurons [4]