文章基本信息

标题：Design of CMOS Based Image Sensor with Cantilever Mechanism for Smart Pathological Detection with Opto-Mechanical System
本地全文：下载
作者：Rajeshlaik ; Vijaynath ; R. N. Gupta 等
期刊名称：International Journal of Electronics and Computer Science Engineering
电子版ISSN：2277-1956
出版年度：2012
卷号：1
期号：3
页码：1281-1291
出版社：Buldanshahr : IJECSE
摘要：This paper specifically objects to the opto-mechanical scanning properties of microscope, PHprobe, and neural properties of ear & brain their equivalent circuitry. Photo-imaging sensor functions to capture & extract the physical, morphological and structural design parameters of the microscopic slide, it becomes the interface between the PC and the object. An aperture of the camera lens is equivalent to the iris of the Eye, focuses on the object distinguishes the clarity of the picture according to resolution. Our Eye iris is equivalent to the camera lens resolution is calculated, for detection of the Eye disorder which varies with focal length, needs more adjustment .The Equivalent circuit of the photo-sensor is described and designed, image Extraction of the microscopic slide with the help of image detection system .(a)Slide before processing of the cancer cells (b) Slide after processing with Hema-toxylin stain (c) Slide under 40x magnification the image of the microscope is extracted using camera attached to microscope lens and the magnified image observed under 40x focusing with the Olympus electronic microscope is extracted with the help of CMOS sensor camera in fluorescent condition .The equivalent mechanisms are miniaturized in the form of CMOS based optic sensor for detection of Eye disorder, It is observed in patients with Eye disorder having 6/6 in left Eye, and plano with right Eye, the power of piezo stress mechanism with legs gives the balanced effect to our neuro-system, compared to the patient with Eye disorder having a diabetic symptom. The power of Eye is detected with ocular refractometer is observed to be reduced to -1. So, the stressing of legs due to walking has proved to be fruitful to eyes. The equivalent CMOS circuit of this biomechanical system was simulated with cadence tools of VLSI, the hardware of this circuit is fabricated at small scale integration, the unknown resistance here is the piezo-stress sensor probe. The PHcantilever sensor is used for early detection of cancer , for detection of Prostate, gastric, Oral cancer, temperature &weighing probe for detection of early etiologies for screening of pancreatic cancer from where the insulin is secreted, Piezo-stress cantilever biosensor if implemented in pathological lab. Early detection of oral cancer is performed at dentistry lab at our local place the fabricated x-ray plate is analyzed, piezo lithography is performed with torch light exposed to the plate, and the teeth arrangement is monitored for their abnormality just by optic mechanism of CMOS sensor. The virtual circuit of the piezo-cantilever device was simulated and found that the output is amplified from μV to Mv, Design of CMOS imaging photo-sensors, was applied to detect the Eye disorder with simple combination of LED & phototransistor, very fast response time to scan (ns) the image. This approach will give us the insight details of pathological slides done by the pathologist, we can use camera attached to microscope and scan the image of the glass slide and detect the field of the slide to spot out the cells, at different magnification, this can be done by moving the rotating knob of microscope to visualize the clear image of the FNAC of pathological slide, thus the comparative analysis of the slide provides us the detailed information of the cell status, this mechanism of the microscope functions and is much similar to the cantilever movement & deflection of the light falling on damaged cells of slide and hence detection with positioning of the slide by scanning with use of CFL light in case of the compound microscope, with lower magnification on which the image sensor is attached for scanning the slide image replacing laser light of AFM. Sharpness knob as we use in electron microscope to change the intensity of the light, this technology has the potential to detect the image with lower magnification from 10x-40x, with dynamic field selection, it is possible to spot out the exact nature of the cell, thus X- Y staging moves the slide to locate the field view and selection of the specific status of cells /tissue. Thus this interaction of the tissue and the objective lens of microscope & CMOS image sensor provides the comfortable detection at various light intensities, which is improved feature compared to AFM (atomic force microscope), The extraction of the slide image at very low power magnification under 10x & 40x range under the microscopy vision, unique combination of photodiode with nMOS & inverter with OPAMP amplifies the voltage of each Pixel. Thus able to detect at low-magnification. The image features of the magnified cells of the cancer