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标题：Prevalence and Clinical Correlates of Hypothyroidism in a school for Children with Mental Retardation
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作者：Shivani Jaswal ; Jasbinder Kaur ; BS Chavan 等
期刊名称：Journal of Indian Association for Child and Adolescent Mental Health
电子版ISSN：0973-1342
出版年度：2011
卷号：7
期号：1
页码：4-12
出版社：Indian Association for Child and Adolescent Mental Health
摘要：Objective: Pediatrician is the first contact in the Pathway to Care in children with Mentalretardation (MR). Following the recent advancements in the area of molecular genetics,understanding of specific conditions of MR or Developmental Delay (DD) is expanding.Hypothyroidism is a treatable metabolic/endocrinological cause of MR.The aim of thisstudy was to determine the prevalence of hypothyroidism in school children with mentalretardation.Material & Methods: The study was conducted with 140 randomly selected school-going children with MR residing at the Government Institute of Mentally RetardedChildren, Chandigarh. Thyroid Stimulating Hormone (TSH) levels were estimated to findout the prevalence of hypothyroidism.Results: The prevalence of hypothyroidism in children with MR was 10.7% with meanTSH levels of 12.08 ± 4.58 mIU/ml. Majority of the children with Down syndrome hadhypothyroidism. Developmental delay was found in all the children. Mean IQ levels weresignificantly lower in children with MR and hypothyroidism when compared witheuthyroid children with MR. Significant negative correlation was present between IQ andTSH levels in the MR children with hypothyroidismConclusion: The results of our study suggest that hypothyroidism may be a causative orexaggerating factor of MR in these children. Hence, mass screening of this treatableendocrine disorder in newborns as well as children diagnosed with MR is stronglyrecommended for identification and intervention of developmental delay in thecommunity.
关键词：mental retardation; hypothyroidism; children; Down Syndrome