文章基本信息

标题：Implementing Systematic Review at the National Toxicology Program: Status and Next Steps
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作者：Linda S. Birnbaum ; Kristina A. Thayer ; John R. Bucher 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2013
卷号：121
期号：4
页码：a108-a109
DOI：10.1289/ehp.1306711
出版社：OCR Subscription Services Inc
摘要：The National Toxicology Program (NTP), an interagency program headquartered at the National Institute of Environmental Health Sciences (NIEHS), carries out a broad range of toxicology research and testing and serves as a resource for identification of substances in our environment that are hazards for human health. One of the ways that the NTP identifies hazards is through carrying out literature- based health assessments. Approximately 2 years ago we began exploring systematic-review methodology as a means to enhance transparency and increase efficiency in summarizing and synthesizing findings from studies in our literature-based health assessments. A systematic review uses an explicit, prespecified approach to identify, select, assess, and appraise the data from studies that focus on addressing a specific scientific question (Institute of Medicine 2011). Although traditionally used to grade the quality of evidence and strength of scientific support for recommendations for clinical practice guidelines and healthcare interventions [Agency for Healthcare Research and Quality (AHRQ) 2012; Guyatt et al. 2011; Higgins and Green 2011], we—and others—were interested in how systematic review methodology might be applied to environmental health questions (Agency for Toxic Substances and Disease Registry 2012; National Research Council 2011; Silbergeld and Scherer 2013; U.S. Environmental Protection Agency 2013; Woodruff and Sutton 2011).