文章基本信息

标题：Evaluation of Biomonitoring Data from the CDC National Exposure Report in a Risk Assessment Context: Perspectives across Chemicals
本地全文：下载
作者：Lesa L. Aylward ; Christopher R. Kirman ; Rita Schoeny 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2013
卷号：121
期号：3
页码：287-294
DOI：10.1289/ehp.1205740
出版社：OCR Subscription Services Inc
摘要：a c k g r o u n d: Biomonitoring data reported in the National Report on Human Exposure to Environmental Chemicals [NER; Centers for Disease Control a nd Prevention (2012)] provide information on the presence and concentrations of > 400 chemicals in human blood and urine. Biomonitoring Equivalents (BEs) and other risk assessment–based values now allow interpretation of these biomonitoring data in a public health risk context. oB j e c t i v e s: We compared the measured biomarker concentrations in the NER with BEs and simi-lar risk assessment values to provide an across-chemical risk assessment perspective on the measured levels for approximately 130 analytes in the NER. Me t h o d s: We identified available risk assessment–based biomarker screening values, includ-ing BEs and Human Biomonitoring-I (HBM-I) values from the German Human Biomonitoring Commission. Geometric mean and 95th percentile population biomarker concentrations from the NER were compared to the available screening values to generate chemical-specific hazard quotients (HQs) or cancer risk estimates. co n c l u s i o n s: Most analytes in the NER show HQ values of < 1; however, some (including acryl-amide, dioxin-like chemicals, benzene, xylene, several metals, di-2(ethylhexyl)phthalate, and some legacy organochlorine pesticides) approach or exceed HQ values of 1 or cancer risks of > 1 × 10–4at the geometric mean or 95th percentile, suggesting exposure levels may exceed published human health benchmarks. This analy sis provides for the first time a means for examining population biomonitoring data for multiple environmental chemicals in the context of the risk assessments for those chemicals. The results of these comparisons can be used to focus more detailed chemical-specific examination of the data and inform priorities for chemical risk management and research
关键词：biomonitoring; Biomo nitoring E quiva lents; blo od; c ance r risk; CDC Na tional ;Exposure Report; hazard quotient; NHANES; risk assessment; urine