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标题：Long-term Exposure to PM_2.5 and Incidence of Acute Myocardial Infarction
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作者：Jaime Madrigano ; Itai Kloog ; Robert Goldberg 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2013
卷号：121
期号：2
页码：192-196
DOI：10.1289/ehp.1205284
出版社：OCR Subscription Services Inc
摘要：Ba c k g r o u n d: A number of studies have shown associations between chronic exposure to particulate air pollution and increased mortality, particularly from cardiovascular disease, but fewer studies have examined the association between long-term exposure to fine particulate air pollution and speci fic cardiovascular events, such as acute myocardial infarction (AMI).oB j e c t i v e: We examined how long-term exposure to area particulate matter affects the onset of AMI, and we distinguished between area and local pollutants.Me t h o d s: Building on the Worcester Heart Attack Study, an ongoing community-wide investi-ga tion examining changes over time in myocardial infarction incidence in greater Worcester, Massachusetts, we conducted a case–control study of 4,467 confirmed cases of AMI diagnosed between 1995 and 2003 and 9,072 matched controls selected from Massachusetts resident lists. We used a prediction model based on satellite aerosol optical depth (AOD) measurements to generate both exposure to particulate matter ≤ 2.5 μm in diameter (PM2.5) at the area level (10 × 10 km) and the local level (100 m) based on local land use variables. We then examined the association between area and local particulate pollution and occurrence of AMI.re s u l t s: An interquartile range (IQR) increase in area PM2.5(0.59 μg/m3) was associated with a 16% increase in the odds of AMI (95% CI: 1.04, 1.29). An IQR increase in total PM2.5(area + local, 1.05 μg/m3) was weakly associated with a 4% increase in the odds of AMI (95% CI: 0.96, 1.11).co n c l u s i o n s: Residential exposure to PM2.5may best be represented by a combination of area and local PM2.5, and it is important to consider spatial gradients within a single metropolitan area when examining the relationship between particulate matter exposure and cardiovascular events
关键词：air pollution