文章基本信息

标题：Airborne Particulate Matter and Acute Lung Inflammation: Strak et al. Respond
本地全文：下载
作者：Maciej Strak ; Nicole A.H. Janssen ; Ilse Gosens 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2013
卷号：121
期号：1
页码：a11-a12
DOI：10.1289/ehp.1205860R
出版社：OCR Subscription Services Inc
摘要：In their article, Strak et al. (2012) connected real-world exposure to markers of acute lung function and inflammation. However, some points in the paper require further explanation. Strak et al. used fractional exhaled nitric oxide (FENO) as a marker of lung inflammation. Exhaled NO is produced throughout the respiratory tract and shows significant variability in source strength across the respiratory tract (Barnes et al. 2010; Kharitonov and Barnes 2001). Factors such as particle size, hygroscopicity, composition, and concentration; lung function parameters; and environmental temperature and humidity (Varghese and Gangamma 2006, 2009), which vary across experimental locations and between participants, modify particle deposition sites in the lung. These changes in the deposition site may influence the amount of NO exhaled. In their paper, Strak et al. (2012) did not discuss how these parameters influenced their conclusions. Thus, how the linear regression model they used accounts for these influences needs to be explained.