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标题：Evaluation of the Association between Arsenic and Diabetes: A National Toxicology Program Workshop Review
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作者：Elizabeth A. Maull ; Habibul Ahsan ; Joshua Edwards 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2012
卷号：120
期号：12
页码：1658-1670
DOI：10.1289/ehp.1104579
出版社：OCR Subscription Services Inc
摘要：a c k g r o u n d: Diabetes affects an estimated 346 million persons globally, and total deaths from diabetes are projected to increase > 50% in the next decade. Understanding the role of environ mental chemicals in the development or progression of diabetes is an emerging issue in environ mental health. In 2011, the National Toxicology Program (NTP) organized a workshop to assess the literature for evi-dence of associations between certain chemicals, including inorganic arsenic, and diabetes and/or obe-sity to help develop a focused research agenda. This review is derived from discussions at that workshop.oB j e c ti v e s: Our objectives were to assess the consistency, strength/weaknesses, and biological plausibility of findings in the scientific literature regarding arsenic and diabetes and to identify data gaps and areas for future evaluation or research. The extent of the existing literature was insufficient to consider obesity as an outcome.da t aso u r c e s, ex t r a c t i o n, a n dsy n t h e s i s: Studies related to arsenic and diabetes or obesity were identified through PubMed and supplemented with relevant studies identified by reviewing the reference lists in the primary literature or review articles.co n c l u s i o n s: Existing human data provide limited to sufficient support for an association between arsenic and diabetes in populations with relatively high exposure levels (≥ 150 μg arsenic/L in drink-ing water). The evidence is insufficient to conclude that arsenic is associated with diabetes in lower exposure (< 150 μg arsenic/L drinking water), although recent studies with better measures of out-come and exposure support an association. The animal literature as a whole was inconclusive; how-ever, studies using better measures of diabetes-relevant end points support a link between arsenic and diabetes
关键词：animal; arsenic toxicity; cell line; chemically induced/epidemiology; cultured cell; dia-;betes; environ ;mental epidemiology; glucose; insulin; metabolism; obesity