文章基本信息

标题：Prenatal and Early Childhood Exposure to Tetrachloroethylene and Adult Vision
本地全文：下载
作者：Kelly D. Getz ; Patricia A. Janulewicz ; Susannah Rowe 等
期刊名称：Environmental Health Perspectives
印刷版ISSN：0091-6765
电子版ISSN：1552-9924
出版年度：2012
卷号：120
期号：9
页码：1327-1332
DOI：10.1289/ehp.1103996
出版社：OCR Subscription Services Inc
摘要：Ba c k g r o u n d: Tetrachloroethylene (PCE; or perchloroethylene) has been implicated in visual impairments among adults with occupational and environmental exposures as well as children born to women with occupational exposure during pregnancy.oB j e c t i v e s: Using a population-based retrospective cohort study, we examined the association between prenatal and early childhood exposure to PCE-contaminated drinking water on Cape Cod, Massachusetts, and deficits in adult color vision and contrast sensitivity. Me t h o d s: We estimated the amount of PCE that was delivered to the family residence from partici pants' gestation through 5 years of age. We administered to this now adult study population vision tests to assess acuity, contrast sensitivity, and color discrimination.re s u l t s: Participants exposed to higher PCE levels exhibited lower contrast sensitivity at inter-mediate and high spatial frequencies compared with unexposed participants, although the differ-ences were generally not statistically significant. Exposed participants also exhibited poorer color discrimination than unexposed participants. The difference in mean color confusion indices (CCI) was statistically significant for the Farnsworth test but not Lanthony's D-15d test [Farnsworth CCI mean difference = 0.05, 95% confidence interval (CI): 0.003, 0.10; Lanthony CCI mean difference = 0.07, 95% CI: –0.02, 0.15].co n c l u s i o n s: Prenatal and early childhood exposure to PCE-contaminated drinking water may be associated with long-term subclinical visual dysfunction in adulthood, particularly with respect to color discrimination. Further investigation of this association in similarly exposed populations is necessary
关键词：color vision; contrast sensitivity; perchloroethylene; tetrachloroethylene