摘要:a c k g r o u n d: Hexabromocyclododecane (HBCD) is a brominated flame retardant used in poly styrene foams in thermal insulation and electrical equipment. The HBCD commercial mixture consists mainly of α, β, and γstereo isomers. Health concerns of HBCD exposure include alterations in immune and reproductive systems, neurotoxic effects, and endocrine disruption. Stereoisomer-specific levels of HBCD have not been measured previously in U.S. food.oB j e c t iv es: We measured HBCD stereo isomer levels in U.S. foods from Dallas, Texas, supermarkets.Me t h o d s: Convenience samples of commonly consumed foods were purchased from supermarkets in Dallas in 2009–2010. Food samples included a wide variety of lipid-rich foods: fish, peanut but-ter, poultry, pork, and beef. Thirty-six individual food samples were collected in 2010 and analyzed for α-, β-, and γ-HBCD stereo isomers using liquid chromatography–tandem mass spectrometry (LC-MS/MS). Ten pooled food samples previously collected in 2009 for a study of total HBCD levels using gas chromatography–mass spectrometry (GC-MS), were reanalyzed for α-, β-, and γ-HBCD stereo isomers using LC-MS/MS.re s u l t s: Of the 36 measured individual foods, 15 (42%) had detectable levels of HBCD. Median (ranges) of α- and γ-HBCD concentrations were 0.003 (< 0.005–1.307) and 0.005 (< 0.010–0.143) ng/g wet weight (ww), respectively; β-HBCD was present in three samples with a median (range) of 0.003 (< 0.005–0.019) ng/g ww. Median levels (range) for α-, β-, and γ-HBCD, in pooled samples were 0.077 (0.010–0.310), 0.008 (< 0.002–0.070), and 0.024 (0.012–0.170) ng/g ww, respectively.co n c l u s i o n s: α-HBCD was detected most frequently and at highest concentrations, followed by γ-, and then β-HBCD, in food samples from Dallas, Texas. Food may be a substantial contributor to the elevated α-HBCD levels observed in humans. These data suggest that larger and more repre-sentative sampling should be conducted