文章基本信息

标题：Anthrax Lethal Toxin Inhibits the Production of Proinflammatory Cytokines
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作者：Aiguo Wu ; Joseph Shiloach ; Darya Alibek 等
期刊名称：Journal of Toxins
印刷版ISSN：2314-5048
电子版ISSN：2314-5056
出版年度：2013
卷号：2013
DOI：10.1155/2013/476909
出版社：Hindawi Publishing Corporation
摘要：In previous studies, we have found that anthrax lethal toxin (LeTx) induces apoptosis in both murine macrophages and human peripheral blood mononuclear cells (PBMCs). In this study, we further report that bacterial cell wall (CW) components of Bacillus (B.) anthracis are powerful inducers of proinflammatory cytokines from the PBMCs. These effects are deprived when the LeTx is present. The major causative element for this suppression is lethal factor (LF) rather than protective antigen (PA). These results indicate that the roles of LeTx in anthrax pathogenesis, particularly its effects on cytokine production, should be reevaluated as our findings and other reports are controversial to the conventional concept.