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标题：Scientific Opinion on the safety and efficacy of L-selenomethionine as feed additive for all animal species
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作者：Gabriele Aquilina ; Alex Bach ; Vasileios Bampidis 等
期刊名称：EFSA Journal
印刷版ISSN：1831-4732
出版年度：2013
卷号：11
期号：5
DOI：10.2903/j.efsa.2013.3219
出版社：European Food Safety Authority (EFSA), Parma
摘要：Selenium is a trace element that is essential for vertebrates and involved in series of vital metabolic functions. Considering the purity of the L-selenomethionine (L-SeMet) under application and the metabolic pathways of SeMet, the FEEDAP Panel considers the use of L-SeMet as safe for all animal species, provided that the maximum total selenium level authorised in feed is respected. The use of in animal nutrition is expected to result in a similar increase in selenium deposition in animal tissues/products as that resulting from other sources of SeMet. To ensure consumer safety from consumption of food originating from animals fed L-SeMet, the FEEDAP Panel concludes that dietary selenium supplementation from the additive should not exceed a maximum of 0.2 mg Se/kg complete feed. In the absence of specific data, the additive should be considered as an irritant to skin and eyes, as a skin sensitiser and as potentially harmful by inhalation. The FEEDAP Panel considers that the use of L-SeMet in feed does not pose an additional risk to the environment, compared with other sources of selenium for which it will substitute, as long as the maximum authorised content in feedingstuffs is not exceeded. L-SeMet is an efficient source of selenium for all species. This conclusion is derived from studies with laying hens and pigs for fattening and, in the case of ruminants, from literature describing the microbial incorporation of selenium from organic sources in the rumen. The FEEDAP Panel made some recommendations concerning (i) the specification, (ii) the use of the compound in premixtures, (iii) the use in water for drinking and (iv) risk reduction when handling the additive.