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标题：Magnesium intervention and blood pressure—A study on risk groups
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作者：Ragnar Rylander ; Tommi Tallheden ; Jürgen Vormann 等
期刊名称：Open Journal of Preventive Medicine
印刷版ISSN：2162-2477
电子版ISSN：2162-2485
出版年度：2012
卷号：2
期号：1
页码：23-26
DOI：10.4236/ojpm.2012.21004
出版社：Scientific Research Publishing
摘要：Hypothesis: Although mineral deficiency in particular magnesium is a known risk factor for cardiovascular disease intervention experiments with magnesium show only modest results. Previously published data suggest that there may be particular risk groups in the population. The study was undertaken to investigate if such risk groups could be identified. Experimental design: Subjects (n = 31) were 50 - 79 years old with no disease. The 24 hour urinary excretion of urea (proxy for acidity), magnesium, calcium, and potassium was measured at two week intervals, with and without intervention with mineral water. Intervention with mineral water comprised 75 mL daily, supplying 3.1 mmol Mg, 2.3 Ca, and 0.02 K. Major results: There was a significant relation between acidity and excretion of magnesium, calcium, and potassium, both at one occasion and regarding changes over time. Among subjects with a high secretion of urea there was an inverse relation between the excretion of magnesium and systolic blood pressure. After intervention with mineral water, there was a strong tendency to a decrease in the systolic blood pressure among those with an initial high excretion of urea and a low excretion of magnesium. Conclusions: The results demonstrate the importance of acid-base conditions for mineral homeostasis and suggest the presence of risk groups in the population, related either to a low intake or to a disorder in the reabsorbtion mechanisms. Mineral water decreased the systolic blood pressure in that particular risk group.
关键词：Acid-Base; Magnesium; Calcium; Mineral Water