文章基本信息

标题：The effects of 90-day feeding of D-psicose syrup in male wistar rats
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作者：Tatsuhiro Matsuo ; Reika Ishii ; Yoko Shirai 等
期刊名称：Open Journal of Preventive Medicine
印刷版ISSN：2162-2477
电子版ISSN：2162-2485
出版年度：2011
卷号：1
期号：2
页码：66-71
DOI：10.4236/ojpm.2011.12010
出版社：Scientific Research Publishing
摘要：D-Psicose is a rare sugar present in small quantities in natural products. In a previous study, we showed that D-psicose suppresses increase in plasma glucose and reduces body fat accumulation in rats. Based on acute and chronic toxicity testing in rats, D-psicose is classified as an ordinary and safe substance. Recently, we developed a high D-psicose syrup (PS) made from high fructose corn syrup (HFCS) by the alkaline isomerization method. However, the safety of PS as a food additive has not been demonstrated. In this study, we investigated the effects of 90-day feeding of PS in male Wistar rats. The rats were fed diets containing 3% D-psicose (control) or 4.3% PS for 90 days. The body weight gain and intra-abdominal adipose tissue weight did not differ between the control and PS group. The weights of the tissues did not differ between the two dietary groups. In clinical chemistry and hematological analyses, no differences were found between the control and PS groups. No gross pathological findings were evident at dietary doses of 4.3% PS. Therefore, the present study found no adverse effects of PS in rats fed a diet containing 4.3% PS for 90 days.
关键词：D-Psicose; D-Psicose Syrup; 90-Day Feeding; Pathological Tests; Rat