文章基本信息

标题：A study on sleep architecture in patients with chronic respiratory failure under long-term oxygen therapy—Focused on the influence of ventilatory failure (high CO₂) elements on the patient’s sleep architecture
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作者：Tsuguo Nishijima ; Keisuke Hosokawa ; Fumitaka Mito 等
期刊名称：Health
印刷版ISSN：1949-4998
电子版ISSN：1949-5005
出版年度：2013
卷号：5
期号：8A2
页码：14-20
DOI：10.4236/health.2013.58A2003
出版社：Scientific Research Publishing
摘要：Sleep disturbance related symptoms are common in patients with long-term oxygen therapy (LTOT). Essentially, there were only few previous reports about the sleep architecture in patients with respiratory disease, such as chronic obstructive pulmonary disease (COPD). This study aims to clarify the objective sleep state and the elements that affect sleep architecture in Chronic Respiratory Failure (CRF) patients with focus on clinical cases of chronic hypercapnia. 13 subjects with chronic respiratory failure were enrolled in the study. All the subjects were pre-evaluated by pulmonary function test and Arterial blood gas analysis (ABG) including exercise testing. Polysomnography (PSG) test was performed in each subject with supplemental oxygen. The estimated base line PaCO₂ value that reflects overall PaCO₂ including sleep period was calculated using equation of PaCO_{2[2.4×(HCO¯}₃_)-22]from obtained ABG value just before PSG test. 6 subjects were classified as hypercapnic group (base line PaCO₂ ≥ 45 mmHg) and 7 subjects were non-hypercapnic group (base line PaCO₂ ₂ were no significant difference. This study suggests that patients with estimated hypercapnia had more disturbed sleep architecture especially significant loss of sleep latency than non-hypercapnic patient with chronic respiratory failure under LTOT. Nocturnal PaCO₂ level or ventilatory function may contribute to sleep disturbance in patients with estimated hypercapnia during LTOT.
关键词：Chronic Respiratory Failure; Long-Term Oxygen Therapy; Sleep Architecture; Periodic Leg Movement Disorder