文章基本信息

标题：Lipoprotein lipase and obesity
本地全文：下载
作者：Masataka Kusunoki ; Kazuhiko Tsutsumi ; Daisuke Sato 等
期刊名称：Health
印刷版ISSN：1949-4998
电子版ISSN：1949-5005
出版年度：2012
卷号：4
期号：12A
页码：1405-1412
DOI：10.4236/health.2012.412A203
出版社：Scientific Research Publishing
摘要：Obesity is one of the fast-growing major diseases in developed and developing countries. As has been persuasively argued, long-term imbalance between intake and expenditure of fat is a central factor in the etiology of obesity. Obesity aggravates insulin resistance and promotes cardiovascular diseases and atherosclerosis. We hypothesized that elevating lipoprOtein lipase (LPL) activity in skeletal muscle would cause an improvement of obesity. To test this hypothesis, we studied the effects of the LPL activator NO-1886 inobese animals. NO-1886 elevated LPL activity in skeletal muscle, and improved obesity as well as insulin resistance in obese rats. Furthermore, NO-1886 mitigated body weight gain induced by pioglitazone without suppressive effect on the adiponectin-increasing action of pioglitazone. LPL activators hold a lot of promise of curing several diseases shown above in clinical scene.
关键词：Lipoprotein Lipase; Lipoprotein Lipase Activator; Insulin Resistance; Lipid Metabolism