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标题：Effects of methanolic extract of Pausinystalia yohimbe bark on blood glucose level in normal fasting rats
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作者：Hozeifa Mohamed Hassan ; Taj Eldin Imad Mohamed ; Elhadi Mohamed Mohamed Ahmed 等
期刊名称：Health
印刷版ISSN：1949-4998
电子版ISSN：1949-5005
出版年度：2012
卷号：4
期号：12
页码：1225-1228
DOI：10.4236/health.2012.412180
出版社：Scientific Research Publishing
摘要：Background: Pausinystalia yohimbe (L.) is a member of the family Rubiaceae. It is a valuable medicinal tree, distributed in evergreen closed-canopy forests in West Africa. It is traditionally used for treatment of erectile dysfunction and diabetes. Objective: This was an attempt to evaluate the effects of methanolic extract of P. yohimbe bark on blood glucose level in normal fasting rats. Methods: Different doses of methanolic extract of P. yohimbe bark (5, 10, 20, 40 and 80 mg/kg/mL) were orally administered to normal fasting rats to assess their effects on blood glucose levels. Results: The methanolic extract of P. yohimbe bark in different concentrations (5, 10, 20, 40 and 80 mg/kg/mL) when administered to normal fasting rats, only a considerable reduction (26.57 mg/dL) was produced by the dose of 20 mg/kg/mL. Conclusion and Recommendation: Although P. yohimbe has long been reported to regulate blood glucose levels; such effect is unclear and remains requiring further studies.
关键词：Pausinystalia yohimbe Bark; Yohimbine; Fasting Blood Glucose Level; Hypoglycemia