文章基本信息

标题：The nature of proteins in influenza
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作者：K. Akila ; P. Balamurugan ; E. Rajasekaran 等
期刊名称：Health
印刷版ISSN：1949-4998
电子版ISSN：1949-5005
出版年度：2012
卷号：4
期号：10A
页码：991-994
DOI：10.4236/health.2012.430151
出版社：Scientific Research Publishing
摘要：Mutation can alter the structure of viral proteins to form different structure. Carbon distribution is responsible for these changes in structure. The carbon distribution in proteins of human Influenza A virus is analyzed here. Results reveal that the carbon contents are high in surface proteins, optimum in polymerase proteins and less in nuclear proteins. Polymerase proteins have better carbon distribution pattern than the other proteins. Thymine distribution in different frames of mRNAs are checked as it has link with carbon distribution pattern in the corresponding proteins. Results show that frame 4 is violating from thymine distribution. This is responsible for production of protein with different carbon distribution. Unusual thymine distribution in frame 3 are observed. The thymine distributions are different in viral mRNA compared to normal one. Minimizing the excess thymine in H1N1 mRNAs might improve the protein performance. Mutational study based on carbon distribution should be better exploited for further improving the protein stability, activity and ultimately for gene therapy.
关键词：Carbon Distribution; Influenza Virus; H1N1; Carbon Study; Protein Analysis; Swine Flu; Proteomics; Transcriptomics