文章基本信息

标题：Aspects on the Mechanism of the 1-Phenyl-1H-pyrazolo[3,4-b]quinoxaline Formation
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作者：Mohamed A. Mostafa ; Salah L. Aboulela ; Mohammed A. E. Sallam 等
期刊名称：Green and Sustainable Chemistry
印刷版ISSN：2160-6951
电子版ISSN：2160-696X
出版年度：2012
卷号：2
期号：2
页码：71-75
DOI：10.4236/gsc.2012.22012
出版社：Scientific Research Publishing
摘要：Condensation of D-glucose, o-phenylenediamine and N,N-benzylphenylhydrazine hydrochloride (NNBPHH) in a one-pot reaction, or condensation of 2-(D-arabino-tetritol-1-yl) quinoxaline and NNBPHH, gave 3-(D-erythro-glycerol-1- yl)-1-phenyl-1H-pyrazolo[3,4-b]quinoxaline. The structure of the latter was determined by 1H NMR spectroscopy and by synthesis using phenylhydrazine hydrochloride instead of NNBPHH. Condensation of D-glucose and 4,5-dichloro-o-phenylenediamine gave 6,7-dichloro-2-(D-arabino-tetritol-1-yl)quinoxaline, which upon condensation with NNBPHH gave the corresponding 6,7-dichloro-3-(D-erythro-glycerol-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]quinoxaline. The structure and mechanism of formation of these compounds are discussed.
关键词：2-(D-arabino-tetritol-1-yl)quinoxaline; Pyrazolo[3;4-b]quinoxalines; 3-(D-erythro-glycerol-1-yl)-1-phenyl-1H-pyrazolo-[3;4-b]qunoxaline; 4;5-Dichloro-o-phenylenediamine; 6;7-Dichloro-2-(D-arabino-tetritol-1-yl)quinoxaline; 6;7-Dichloro-3-(D-erythro-glycerol-1-yl)-1-phenyl-1H-pyrazolo-[3;4-b]quinoxaline; N;N-Benzylphenylhydrazine hydrochloride