文章基本信息

标题：Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions
本地全文：下载
作者：Sara Castiglioni ; Alessandra Cazzaniga ; Walter Albisetti 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2013
卷号：5
期号：8
页码：3022-3033
DOI：10.3390/nu5083022
语种：English
出版社：MDPI Publishing
摘要：A tight control of magnesium homeostasis seems to be crucial for bone health. On the basis of experimental and epidemiological studies, both low and high magnesium have harmful effects on the bones. Magnesium deficiency contributes to osteoporosis directly by acting on crystal formation and on bone cells and indirectly by impacting on the secretion and the activity of parathyroid hormone and by promoting low grade inflammation. Less is known about the mechanisms responsible for the mineralization defects observed when magnesium is elevated. Overall, controlling and maintaining magnesium homeostasis represents a helpful intervention to maintain bone integrity.
关键词：osteoporosis; magnesium; osteoblast; osteoclast