文章基本信息

标题：Calcium Regulation and Bone Mineral Metabolism in Elderly Patients with Chronic Kidney Disease
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作者：Vickram Tejwani ; Qi Qian
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2013
卷号：5
期号：6
页码：1913-1936
DOI：10.3390/nu5061913
语种：English
出版社：MDPI Publishing
摘要：The elderly chronic kidney disease (CKD) population is growing. Both aging and CKD can disrupt calcium (Ca2+) homeostasis and cause alterations of multiple Ca2+-regulatory mechanisms, including parathyroid hormone, vitamin D, fibroblast growth factor-23/Klotho, calcium-sensing receptor and Ca2+-phosphate product. These alterations can be deleterious to bone mineral metabolism and soft tissue health, leading to metabolic bone disease and vascular calcification and aging, termed CKD-mineral and bone disorder (MBD). CKD-MBD is associated with morbid clinical outcomes, including fracture, cardiovascular events and all-cause mortality. In this paper, we comprehensively review Ca2+ regulation and bone mineral metabolism, with a special emphasis on elderly CKD patients. We also present the current treatment-guidelines and management options for CKD-MBD.
关键词：calcium homeostasis; aging; chronic kidney disease; mineral and bone disorder; vascular calcification; secondary hyperparathyroidism