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标题：COMPARATIVE EFFECT OF ENALAPRIL AND CATOPRIL IN NORMOTENSIVE PATIENTS WITH INCIPIENT DIABETIC NEPHROPATHY
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作者：R. R. SINGH ; PRATAP SHANKAR ; R. C. VERMA 等
期刊名称：Indian Streams Research Journal
印刷版ISSN：2230-7850
出版年度：2013
卷号：II
期号：XII
出版社：Indian Streams Research Journal
摘要：Objective- To see the effect of enalapril and captopril on patients with diabetes and impending diabetic nephropathy. Material Methods- Study was performed in patients suffering with long term diabetes mellitus. A total of 61 normotensive patients of diabetes having persistent microproteinurea were selectedwith age >30 years, Informed consent was taken from all patients and a strict compliance of the drugs during the study was ensured.The patients those selected were given enalapril 2.5 mg daily or captopril 25 mg daily in two divided doses or placebo for a period of three months. The dietary instructions and anti-diabetic treatment at the beginning of the trial remained unchanged during the study. Results and Conclusion:- Both captopril and enalapril reduced protenuria significantly as compared to the placebo group. Regarding the serum creatintine level there was no significant alteration in both groups as compared to placebo.
关键词：Diabetes mellitus; Nephropathy; Captopril; Enalapril; ACE inhibitors.