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标题：Relationship between serum and csf glucose in subarachnoid hemorrhage
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作者：Sayantani Ghosh ; Saugat Dey ; Mitchell Maltenfort 等
期刊名称：International Journal of Collaborative Research on Internal Medicine & Public Health
电子版ISSN：1840-4529
出版年度：2012
卷号：4
期号：5
出版社：DRUNPP Sarajevo
摘要：Introduction: There has been considerable controversy regarding the effect of serum and cerebrospinal fluid (csf) glucose levels in the prognosis of aneurysmal subarachnoid hemorrhage (aSAH) patients. Objective: We have explored the relationship between serum and csf glucose serum glucose levels in such patients and have also explored the levels of serum and csf glucose required to maintain a good outcome. Methods: Retrospective review of 2000 aSAH patients, from a prospectively collected database of Thomas Jefferson University Hospital, was done. The Hunt-Hess (H-H) grade of the SAH, cerebral and serum glucose on admission, serum glucose on the day of surgery and 14 days post the surgery as well as the GOS-E score at discharge was noted. Parameters were analyzed individually for significance via contingency tables and significant parameters (p < 0.05) were further examined. Relationship between serum and csf glucose is established via Spearman's rank correlation coefficient. Result: Correlation between csf and serum glucose at admission was found to be 0.52, it increased from HH grade 1-4 and then became negative but more tightly bound at HH5. Serum glucose higher than 151.58 mg/dl (95% confidence interval, 141.36- 160.63) and csf glucose higher than 77.83 mg/dl (95% confidence interval, 75.05- 80.61) was found to be associated with worse outcome. 95.57% of the patients, who had even a single event of hypoglycemia, have had a previous episode of hyperglycemia and fared badly. Csf glucose < 38 mg/dl also led to more deaths. Conclusion
关键词：Aneurysmal subarachnoid hemorrhage; serum glucose; cerebral glucose; correlation; extended Glasgow outcome score