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标题：A combination of various functional food ingredients as a weight management program: randomized, placebo-controlled, and double-blind human clinical studies
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作者：Harunobu Amagase
期刊名称：Functional Foods in Health and Disease
电子版ISSN：2160-3855
出版年度：2011
卷号：1
期号：12
出版社：Food Science Publisher
摘要：:Background: Lycium barbarum increased the postprandial energy expenditure (PPEE). Negative energy balance caused by the systematic procedure (TAIslim® System), including increasing metabolic rate through physical activity, use of Lycium barbarum-containing TAIslim (Product A), and decreasing caloric intake by consuming a chewable confection (TAIslim SKINNY=Product B), and a meal replacement shake (TAIslim SHAKE=Product C), would be successful for weight loss.Methods: We examined TAIslim System on anthropometrics, appetite in Study 1 and PPEE in Study 2, both in a randomized, placebo-controlled, double-blind manner. 1) A total of 67 participants were randomized into 2 groups (placebo or TAIslim System). Intake procedures were: Product A, 60 ml (20 kcal) b.i.d. immediately before breakfast and lunch, Product B, 1 chew (20 kcal) t.i.d. between meals and after dinner; Product C, 40.5 g (158 kcal) as breakfast. A calorie-restricted diet with multi-vitamin supplementation and daily exercise was required. Anthropometric parameters were assessed at baseline, 4, 8, and 12 w. 2) Appetite was measured using a subjective visual analog scale during the initial 3-7 days of intake. 3) For PPEE evaluation, 12 participants consumed a single bout of TAIslim System products or placebo, and took part in 6 study sessions. EE was measured by an indirect calorimeter immediately before (baseline) and at 1, 2, and 4 h post-intake of samples.Results: 1) Body weight was significantly reduced by 6.2±0.7%, compared to pre-intervention with TAIslim System (P
关键词：Lycium barbarum | Goji | Fiber | Phenylalanine | N-Acetyl-L-Tyrosine | Tea | Polyphenols | Human clinical trial | Energy expenditure | Resting metabolic rate | Waist circumference | Appetite | Body mass index | TAIslim