文章基本信息

标题：Silica Aerogel Improves the Biocompatibility in a Poly-<svg style="vertical-align:-0.18pt;width:11.225px;" id="M1" height="10.7" version="1.1" viewBox="0 0 11.225 10.7" width="11.225" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"> <g transform="matrix(.022,-0,0,-.022,.062,10.412)"><path id="x1D73A" d="M451 389l-18 -7q-3 4 -19 20q-24 20 -84 20q-52 0 -90 -32q-37 -31 -37 -76q0 -24 16.5 -37.5t43.5 -13.5q8 0 31 4q28 5 43 5q47 0 47 -22q0 -37 -65 -37q-5 0 -28 3t-31 3q-39 0 -77 -31q-39 -30 -39 -78q0 -36 27.5 -55.5t73.5 -19.5q43 0 76.5 17.5t74.5 61.5l18 -8
q-92 -116 -224 -116q-71 0 -116.5 31t-45.5 77q0 48 29.5 86.5t78.5 55.5v3q-21 7 -35 26.5t-14 40.5q0 62 61 107q62 45 166 45q47 0 87 -21.5t50 -51.5z" /></g> </svg>-Caprolactone Composite Used as a Tissue Engineering Scaffold
本地全文：下载
作者：Jianhua Ge ; Musen Li ; Qingguo Zhang 等
期刊名称：International Journal of Polymer Science
印刷版ISSN：1687-9422
电子版ISSN：1687-9430
出版年度：2013
卷号：2013
DOI：10.1155/2013/402859
出版社：Hindawi Publishing Corporation
摘要：Poly--caprolactone (PCL) is a biodegradable polyester that has received great attentions in clinical and biomedical applications as sutures, drug delivery tool, and implantable scaffold material. Silica aerogel is a material composed of SiO2 that has excellent physical properties for use in drug release formulations and biomaterials for tissue engineering. The current study addresses a composite of silica aerogel with PCL as a potential bone scaffold material for bone tissue engineering. The biocompatibility evaluation of this composite indicates that the presence of silica aerogel effectively prevented any cytotoxic effects of the PCL membrane during extended tissue culture periods and improved the survival, attachment, and growth of 3T3 cells and primary mouse osteoblastic cells. The beneficial effect of silica aerogel may be due to neutralization of the acidic condition that develops during PCL degradation. Specifically, it appears that silica aerogel to PCL wt/wt ratio at 0.5 : 1 maintains a constant pH environment for up to 4 weeks and provides a better environment for cell growth.