文章基本信息

标题：T1R3: A human calcium taste receptor
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作者：Michael G. Tordoff ; Laura K. Alarcón ; Sitaram Valmeki 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2012
卷号：2
DOI：10.1038/srep00496
出版社：Springer Nature
摘要：
Many animals can detect the taste of calcium but it is unclear how or whether humans have this ability. We show here that calcium activates hTAS1R3-transfected HEK293 cells and that this response is attenuated by lactisole, an inhibitor of hT1R3. Moreover, trained volunteers report that lactisole reduces the calcium intensity of calcium lactate. Thus, humans can detect calcium by taste, T1R3 is a receptor responsible for this, and lactisole can reduce the taste perception of calcium by acting on T1R3.
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