文章基本信息

标题：DoMosaic - Analysis of the Mosaic-like Domain Arrangements in Proteins
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作者：David T. Gerrard ; Erich Bornberg-Bauer
期刊名称：Informatica
印刷版ISSN：1514-8327
电子版ISSN：1854-3871
出版年度：2003
卷号：27
期号：1
页码：15-20
出版社：The Slovene Society Informatika, Ljubljana
摘要：Sequence analysis is widely used to infer function from one protein sequence to another. One of the remaining hurdles in pushing further the limits of efficient usage is the modular and mobile architecture of proteins. Although many resources provide precompiled signatures, they are not yet used in conjunction with pairwise comparisons to investigate the modular architecture and phylogeny. We present a program, doMosaic, which combines existing domain definitions with an adapted sequence alignment algorithm to analyse the possible phylogeny of domain architecture in proteins. It is based on the Smith-Waterman scheme, can be combined with trees derived from the domains and provides a user-friendly graphical interface. The method enables fast and efficient analysis of domain duplication events within one or in-between two sequences. Therefore, it enables refined functional annotation
关键词：sequence analysis; domain evolution; data visualisation