文章基本信息

标题：Role of PGC-1α in muscle function and aging
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作者：Chounghun Kang ; Li Li Ji
期刊名称：Journal of Sport and Health Science
印刷版ISSN：2095-2546
出版年度：2013
卷号：2
期号：2
页码：1-6
DOI：10.1016/j.jshs.2013.03.005
出版社：Elsevier
摘要：This article focuses on the current underlying of molecular mechanisms of the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) mediated pathway and discuss possible therapeutic benefits of increased mitochondrial biogenesis in compensating for mitochondrial dysfunction and ameliorating aging and aging-related diseases. PGC-1α is the master transcription regulator that stimulates mitochondrial biogenesis, by upregulating nuclear respiratory factors and mitochondrial transcription factor A, leading to increased mitochondrial DNA replication and gene transcription. PGC-1α also regulates cellular oxidant-antioxidant homeostasis by stimulating the gene expression of superoxide dismutase-2, catalase, glutathione peroxidase 1, and uncoupling protein. Recent reports from muscle-specific PGC-1α overexpression underline the benefit of PGC-1α in muscle atrophy and sarcopenia, during which PGC-1α enhanced mitochondrial biogenic pathway and reduced oxidative damage. Thus, PGC-1α seems to have a protective role against aging associated skeletal muscle deterioration.
关键词：Aging ; Mitochondria ; Muscle ; PGC-1α ; Signaling