文章基本信息

标题：Mitochondrial redox metabolism in aging: Effect of exercise interventions
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作者：Hai Bo ; Ning Jiang ; Li Li Ji 等
期刊名称：Journal of Sport and Health Science
印刷版ISSN：2095-2546
出版年度：2013
卷号：2
期号：2
页码：1-8
DOI：10.1016/j.jshs.2013.03.006
出版社：Elsevier
摘要：Mitochondrial redox metabolism has long been recognized as being central to the effects of aging and the development of age-related pathologies in the major oxidative organs. Consistent evidence has shown that exercise is able to retard the onset and impede the progression of aging by modifying mitochondrial oxidant–antioxidant homeostasis. Here we provide a broad overview of the research evidence showing the relationship between mitochondrial redox metabolism, aging and exercise. We address part aspects of mitochondrial reactive oxygen species (ROS) metabolism, from superoxide production to ROS detoxification, especially antioxidant enzymes and uncoupling protein. Furthermore, we describe mitochondrial remodeling response to aging and exercise, which is accompanied by bioenergetics and redox regulation. In addition, potential mechanisms for redox signaling involved in mitochondrial remodeling and redox metabolism regulation are also reviewed.
关键词：Aging ; Exercise ; Mitochondrial remodeling ; PGC-1α ; Reactive oxygen species