Stating the main principles of Buddhist philosophy and psychology is usually going with help of ancient categories and metaphors, which had been developed since the fifth century B.C. till the tenth century A.C. That means they were worked out by quite different kind of mentality (culture, language, traditions…). That makes those categories and metaphors almost untranslatable on European languages properly and unequivocally. In its turn, that situation makes difficult any kind of modern scientific research of the phenomena, discovered inside Buddhism, as well as ideas, developed in it. In this article we set a question of possibility to select such basic concepts of modern natural science, which can effectively translate main oriental ideas about Reality into modern scientific paradigm and discover the meaning of psychological phenomena from the transpersonal psychology sphere of interest. We take a look on some comparisons between pictures of Reality in modern physics and in Buddhist paradigm, allocating two sides of Reality, called Nirvana and Samsara.