文章基本信息

标题：Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol
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作者：Sarah J. Mitchell ; Alice E. Kane ; Sarah N. Hilmer 等
期刊名称：Current Gerontology and Geriatrics Research
印刷版ISSN：1687-7063
电子版ISSN：1687-7071
出版年度：2011
卷号：2011
DOI：10.1155/2011/624156
出版社：Hindawi Publishing Corporation
摘要：Optimal pharmacotherapy is determined when the pharmacokinetics and pharmacodynamics of the drug are understood. However, the age-related changes in pharmacokinetics and pharmacodynamics, as well as the increased interindividual variation mean optimal dose selection are a challenge for prescribing in older adults. Poor understanding of how hepatic clearance and toxicity are different with age results in suboptimal dose selection, poor efficacy, and/or increased toxicity. Of particular concern is the analgesic paracetamol which has been in use for more than 50 years and is consumed by a large proportion of older adults. Paracetamol is considered to be a relatively safe drug; however, caution must be taken because of its potential for toxicity. Paracetamol-induced liver injury from accidental overdose accounts for up to 55% of cases in older adults. Better understanding of how age affects the hepatic clearance and toxicity of drugs will contribute to evidence-based prescribing for older people, leading to fewer adverse drug reactions without loss of benefit.