文章基本信息

标题：Computational Modeling for the Activation Cycle of G-proteins by G-protein-coupled Receptors
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作者：Yifei Bao ; Adriana Compagnoni ; Joseph Glavy 等
期刊名称：Electronic Proceedings in Theoretical Computer Science
电子版ISSN：2075-2180
出版年度：2010
卷号：40
页码：39-53
DOI：10.4204/EPTCS.40.4
出版社：Open Publishing Association
摘要：In this paper, we survey five different computational modeling methods. For comparison, we use the activation cycle of G-proteins that regulate cellular signaling events downstream of G-protein-coupled receptors (GPCRs) as a driving example. Starting from an existing Ordinary Differential Equations (ODEs) model, we implement the G-protein cycle in the stochastic Pi-calculus using SPiM, as Petri-nets using Cell Illustrator, in the Kappa Language using Cellucidate, and in Bio-PEPA using the Bio-PEPA eclipse plug in. We also provide a high-level notation to abstract away from communication primitives that may be unfamiliar to the average biologist, and we show how to translate high-level programs into stochastic Pi-calculus processes and chemical reactions.