文章基本信息

标题：Clinical features and lifestyle of patientswith amyotrophic lateral sclerosis in Campania:brief overview of an Italian database
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作者：Francesca Trojsi ; Anna Sagnelli ; Nicola Vanacore 等
期刊名称：Annali dell'Istituto Superiore di Sanita
印刷版ISSN：0021-2571
出版年度：2012
卷号：48
期号：03
页码：287-291
DOI：10.4415/ANN_12_03_09
出版社：Editrice Kurtis Srl
摘要：Background. Physical activity and occupational exposures appeared to play a relevant role in pathogenesis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease of unknown origin. Materials and methods. We aimed to make an overview of the clinical characteristics and lifestyle (occupation and sport) of a population of 395 patients with ALS from Campania, in southern Italy. Results. ALS onset resulted anticipated of about 11 years in industry workers, whilst the more frequent site of onset among farmers was upper limbs. Compared to non-athletes, athletes, particularly soccer players, showed a 7 years anticipation of ALS onset, with higher mortality after 5 years. Discussion and conclusions. We suggest that subjects genetically prone to abnormal response to hypoxia during strenuous physical activity or exposed to neurotoxic agents, such as athletes, farmers or industry workers, might present increased risk to develop ALS. Future case-control and follow-up studies on our population should be implemented to deepen the present results.200
关键词：amyotrophic lateral sclerosis; motor neuron diseases; clinical database; occupational exposure.