文章基本信息

标题：The Influence of Clinical and Anthropometric Parameters on the Serum Levels of the Endothelin-1 in Pregnant Women and their Newborns
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作者：Vukelić Šarunić, Alenka ; Cvijanović, Olga ; Đudarić, Luka 等
期刊名称：Collegium Antropologicum
印刷版ISSN：0350-6134
出版年度：2012
卷号：36
期号：2
页码：395-400
出版社：Hrvatsko antropološko društvo
摘要：Pregnancy induced hypertension (PIH) is major contributor to maternal death in developing countries. Endothelin-1 (ET-1) is the most potent vasoconstriction agent known and its serum levels are increased in PIH. Therefore it is important to elucidate maternal and neonatal factors which influence endothelin-1 serum levels. 100 pathological pregnancies and 88 controls were analyzed for blood endothelin-1 and their anthropometric and clinical data were collected. In maternal blood ET-1 levels were strongly predicted by diagnosis, therapy and BMI, while umbilical cord ET-1 levels were strongly predicted by gestational age, therapy and delivery termination. Positive correlation between BMI and ET-1 levels suggest that obese pregnant women have increased risk for cardiovascular diseases. Inverse relationship between Apgar and umbilical ET-1 indicates that ET-1 could be considered as a prognostic marker in cases of neonatal asphyxia.
关键词：endothelin-1; pregnancy induced hypertension; anthropometry; apgar