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标题：Ramipril and Risk of Hyperkalemia in Chronic Hemodialysis Patients
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作者：Krajina-Andričević, Mirna ; Zibar, Lada ; Juras, Karin 等
期刊名称：Collegium Antropologicum
印刷版ISSN：0350-6134
出版年度：2011
卷号：35
期号：2
页码：537-542
出版社：Hrvatsko antropološko društvo
摘要：Angiotensin converting enzyme (ACE) inhibitors provide well known cardiorenal-protective benefits added to antihypertensive effects in chronic renal disease. These agents are underused in management of patients receiving hemodialysis (HD) because of common concern of hyperkalemia. However, few studies have investigated effect of renin angiotensin aldosterone system (RAAS) blockade on serum potassium in hemodialysis patients. We assessed the safety of ramipril in patients on maintenance HD. We enrolled 28 adult end stage renal disease (ESRD) patients treated by maintenance HD and prescribed them ramipril in doses of 1.25 to 5 mg per day. They underwent serum potassium concentration measurements before ramipril introduction and in 1 to 3 months afterwards. No significant increase in kalemia was found. Results of our study encourage the use of ACE inhibitors in chronically hemodialyzed patients, but close potassium monitoring is mandatory.
关键词：angiotensin converting enzyme inhibitors; hyperkalemia; hemodialysis