文章基本信息

标题：Tumor Markers in Breast Cancer – Evaluation of their Clinical Usefulness
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作者：Marić, Petra ; Ozretić, Petar ; Levanat, Sonja 等
期刊名称：Collegium Antropologicum
印刷版ISSN：0350-6134
出版年度：2011
卷号：35
期号：1
页码：241-247
出版社：Hrvatsko antropološko društvo
摘要：Breast cancer is the most common neoplasm affecting women in the Western world. Many studies are still conducted with the purpose of finding markers that could be used for early diagnosis and/or serve as possible reliable prognostic or predictive parameters, but with conflicting results. At present, no markers are available for an early diagnosis of breast cancer. For surveillance of patients with diagnosed breast cancer the most widely used serum markers are CA 15-3 and CEA which, in combination with other clinical parameters, could have clinical significance. The most useful and clinically important tissue-based markers in breast cancer are estrogen and progesterone receptors, used as a basis for hormonal therapy, and HER-2 receptors, essential in selecting patients for the treatment with Herceptin®. New or potentially new markers for breast cancer include BRCA1 and BRCA2 genes for selecting patients at high risk of developing hereditary breast cancer, as well as urokinase plasminogen activator and inhibitor for assessing prognosis in lymph node-negative patients. Results of tumor and patient genetic analyses including their clinical evaluation will enable application of more individualized and personalized approach in diagnosis and therapy of breast cancer patients.
关键词：breast cancer; serum tumor markers; tissue tumor markers; genetic tumor markers; clinical application