文章基本信息

标题：Predicted Coronary Heart Disease Risk in Croatian HIV Infected Patients Treated with Combination Antiretroviral Therapy
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作者：Turčinov, Drago ; Begovac, Josip
期刊名称：Collegium Antropologicum
印刷版ISSN：0350-6134
出版年度：2011
卷号：35
期号：1
页码：115-121
出版社：Hrvatsko antropološko društvo
摘要：We assessed the coronary heart disease (CHD) risk in 130 HIV-infected patients with no major past cardiovascular event treated with combination antiretroviral therapy (CART) between May 2004 and June 2005. We also investigated the association of HIV disease parameters (CD4+ T-cell counts, HIV viral load, AIDS diagnosis, antiretroviral medications and lipodystrophy), demographics, anthropometrics, clinical features, smoking status, dyslipidemia, adherence to the Mediterranean diet, and the metabolic syndrome (MS) to the Framingham risk score. The median 10-year CHD risk was 6.4% (IQR 3.3–13.0) for males and 1.8% (IQR 1.0–6.7) for females. The CHD risk was ³10% in 31.1% (32 of 103) males and in 14.8% (4 of 27) females. MS was present in 27 (20.8%) individuals. Participants who met the definition of the MS had a 2.63 times greater chance of having a CHD risk ³10% (95% CI, 1.09–6.39; p=0.032). On multivariable analysis, we found that a CHD risk ³10% was associated with: a lowest ever CD4+ T-cell counts of less than 50 per microliter and a past history of AIDS (OR, 6.26; 95% CI, 1.61–24.36; p=0.008); alcohol consumption ³10 g/day (OR, 3.87; 95% CI, 1.56–14.22; p=0.041); and age ³43 years (OR, 1.30; 95% CI, 1.17–1.45; p the modifiable cardiovascular risk are needed in Croatian patients treated with CART.
关键词：HIV; coronary heart disease; Framingham risk score; metabolic syndrome