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标题：Real-Time Expression of hTERT in Primary Melanoma Biopsies
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作者：Katunarić, Miljenko ; Jurišić, Davor ; Hadžisejdić, Ita 等
期刊名称：Collegium Antropologicum
印刷版ISSN：0350-6134
出版年度：2010
卷号：34
期号：4
页码：1401-1404
出版社：Hrvatsko antropološko društvo
摘要：Skin melanoma is by far the most lethal skin cancer, it is unpredictable by nature and presents a severe diagnostic problem. One of the major issues in melanoma diagnostics is to differentiate it with confidence from a dysplastic nevus. Thus, the aim of this study was to evaluate hTERT expression on a spectrum of dermal lesions (from normal skin to primary melanoma) in order to examine its possible role as a diagnostic marker in melanoma diagnostics. In this study we analyzed the expression of hTERT by real-time PCR on 58 freshly obtained biopsy samples (4 samples of normal skin, 12 dermal nevi, 23 dysplastic nevi, 19 primary melanomas). Our results showed slightly greater hTERT expression in dysplastic nevi than melanomas with major data overlap. Considering the given results, hTERT does not seem to be a reliable diagnostic marker for melanoma.
关键词：hTERT; primary melanoma; Real-Time; expression; biopsies