文章基本信息

标题：Drug-Induced Aseptic Meningitis, Sensorineural Hearing Loss and Vestibulopaty
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作者：Sepčić, Juraj ; Bučuk, Mira ; Perković, Olivio 等
期刊名称：Collegium Antropologicum
印刷版ISSN：0350-6134
出版年度：2010
卷号：34
期号：3
页码：1101-1104
出版社：Hrvatsko antropološko društvo
摘要：We report clinically rare and serious adverse reactions that occurred after the co-administration of ranitidine, ibuprofen and ciprofloxacin: completely reversible aseptic meningitis and irreversible bilateral sensorineural hearing loss, tinnitus, and vestibulopathy. Recurrent urinary inflammations treated with antibacterials, classic familial migraine, and allergy to trimethoprim-sulfamethoxazole and chromium were favourable predisposing factors for the adverse event in this patient. A close chronological relation between administration of drugs (especially ibuprofen) and adverse reactions was noted. No evidence of infection and/or autoimmune disease was found. The mechanism of these serious events may be explained as a hypersensitive reaction affecting the meninges and, partially, cochlea.
关键词：ranitidine; ibuprofen; ciprofloxacin; drug interactions; aseptic meningitis; deafness