文章基本信息

标题：Pyostomatitis Vegetans Associated with Inflammatory Bowel Disease – Report of Two Cases
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作者：Mijandrušić-Sinčić, Brankica ; Licul, Vanja ; Gorup, Lari 等
期刊名称：Collegium Antropologicum
印刷版ISSN：0350-6134
出版年度：2010
卷号：34 supplement 2
期号：2
页码：279-282
出版社：Hrvatsko antropološko društvo
摘要：Pyostomatitis vegetans (PV) is a rare, chronic mucocutaneous disorder associated with inflammatory bowel disease (IBD). Oral lesions of PV are distinct and present as multiple white or yellow pustules with an erythematous base that coalesce and undergo necrosis to form a typical »snail tracks« appearance. Two cases of PV associated with IBD – one with Crohn's disease (CD) and the other with ulcerative colitis (UC) are reported. In the first case, adalimumab therapy brought the oral and gastrointestinal manifestations to complete remission. In the second case, the remission was achieved with systemic steroid therapy, but the disease relapsed after therapy discontinuation. Azathioprine was added leading to sustained remission of PV. Because of persistent active intestinal manifestation of UC, in spite of immunosuppressive therapy, infliximab was introduced. With the therapy remission of intestinal manifestation of UC was achieved as well. Our cases confirm previously reported good experience with immunomodulators and biologics in the treatment of PV. But, before using them we have to exclude an infectious etiology of oral lesions.
关键词：pyostomatitis vegetans; inflammatory bowel disease; corticosteroids; azathioprine; adalimumab; infliximab