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标题：Lymphomatoid Granulomatosis in a 23-year-old Man – Cytological and Histological Typing and Rapid Response to Steroid and Cyclophosphamide Combination Therapy
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作者：Rakušić, Neven ; Krmpotić, Diana ; Hećimović, Ana 等
期刊名称：Collegium Antropologicum
印刷版ISSN：0350-6134
出版年度：2010
卷号：34
期号：1
页码：279-283
出版社：Hrvatsko antropološko društvo
摘要：Lymphomatoid granulomatosis (LG) is currently called as extranodal angiocentric and angiodestructive immunoproliferative disorder with various degrees of histological differentiation and disease severity. Histological grading and clinical manifestations are due to number of atypical large EBV+ B-lymphatic cells. We report the case of a 23-year-old man clinically presented with fever, sweating, and physical intolerance, and bilateral pulmonary infiltrates of nodular type and destructive changes on the chest X-ray, previously treated with antituberculotics for 1.5 month. As the disease showed progression, diagnostic procedures extended to transbronchial lung biopsy and percutaneous fine needle aspiration with cytological and histological analysis of collected specimens, all being not conclusive enough. LG was confirmed by open lung biopsy, followed by induction of corticosteroids and cyclophosphamide therapy. Very good clinical, functional and radiomorphologic improvement was achieved in a few weeks, and remission of disease maintained in long term follow-up.
关键词：lymphomatoid granulomatosis; pulmonary nodular infiltrates; open lung biopsy; EBV+ B-lymphatic cells